Arteriosclerosis, Thrombosis, and Vascular Biology , 2005
نویسندگان
چکیده
منابع مشابه
Hemostasis, Thrombosis, and Vascular Biology
Duringhumanfulminanthepatic failure (FHF) circulating levels of most hemostatic proteins fall dramatically. Concurrently, factor VIII (fVIII) procoagulant activity rises despite destruction of the hepatocytes considered responsible for fVIII synthesis. This observation suggests a role for cells other than hepatocytes in fVIII biosynthesis during FHF. We have attempted to identify nonhepatocytic...
متن کاملHemostasis, Thrombosis, and Vascular Biology
It has been established that amelioration of murine immune thrombocytopenia purpura (ITP) by IVIg is dependent on the inhibitory receptor Fc RIIB. Co–cross-linking of the Fc RIIB with the B-cell receptor complex or with Fc RI in mast cells results in cell inhibition, which is mediated by recruitment of the inositol phosphatase SHIP1 to the cytoplasmic tail of the Fc R. The Fc RIIB can also asso...
متن کاملHemostasis, Thrombosis, and Vascular Biology
A20 binding inhibitor of NFB activation-2, ABIN-2, is a newly identified intracellular protein that interacts with the zinc finger protein A20. ABIN-2 inhibits nuclear factor– B (NFB) activity and is a possible effector of A20 regulation of NFB. Although A20 is a potent inhibitor of endothelial apoptosis, the effect of ABIN-2 on apoptosis is not known. ABIN-2 also interacts with the endothelial...
متن کاملHemostasis, Thrombosis, and Vascular Biology
Congenital thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is associated with an inherited von Willebrand factor–cleaving protease (ADAMTS13 [a disintegrin and metalloprotease with thrombospondin type I domains 13]) deficiency. In this study, we identified novel mutations in the ADAMTS13 gene in a patient with TTP. The patient was a 51-year-old Japanese male who exhibite...
متن کاملHemostasis, Thrombosis, and Vascular Biology
1Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA; 2Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA; 3Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA; 4Department of Organismic and Evolutionary Biology, ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000151931.91737.00